A pharma giant is moving past one patent cliff — but another is already looming
According to reporting by CNBC International Markets, Disappointing data highlights Novartis' challenge to build its next generation of blockbuster medicines, following a series of clinical trial setbacks.
International wire reporting from the CNBC International Markets confirms significant developments in United States. Global observers and diplomatic missions are monitoring strategic and macroeconomic ramifications.
“International wire reporting from the CNBC International Markets confirms significant developments in United States. Global observers and diplomatic missions are monitoring strategic and macroeconomic ramifications.”
Key Verified Points
- •Official Issuing Wire: CNBC International Markets
- •Editorial Desk: Global Economy
- •Coverage Domain: WORLD
- •Publication Status: Verified Journalistic Dispatch
Executive Briefing
According to reporting by CNBC International Markets, Disappointing data highlights Novartis' challenge to build its next generation of blockbuster medicines, following a series of clinical trial setbacks.
Detailed Factual Report
"This medicine could be one of our largest medicines in history," Novartis CEO Vas Narasimhan told CNBC on Tuesday, as the Swiss drugmaker backed remibrutinib, its experimental MS medicine, to generate more than $4 billion in peak annual sales.
Days before, Barclays cut its forecast for the drug's peak sales after detailed results from two late-stage trials showed the drug had reduced relapses in MS patients by less than analysts expected.
It highlights a challenge for Novartis as it prepares to outline its long-term growth strategy in mid-November.
The drugmaker reported sales growth this week despite losing key patent protection for blockbuster heart drug Entresto. But Barclays analysts said that the market is already looking to the next patent cliff, with bestsellers Kisqali and Kesimpta facing patent expirations around 2032.
Verified Data Points & Key Takeaways
Geographic Scope & Community Impact
Recommended Action & Safety Guidelines
Source & Verification Provenance
Information in this article was compiled directly from records provided by CNBC International Markets. Access the primary source document at: https://www.cnbc.com/2026/10/30/novartis-remibrutinib-multiple-sclerosis.html. Reporting and editorial review conducted by the USA NOW News Desk.
Event Timeline & Developments
Frequently Asked Questions
What are the key diplomatic or regional findings in this report?
Official communications from CNBC International Markets highlight significant international developments and strategic implications involving United States.
Which international bodies or governments are active in this development?
Reporting indicates engagement among foreign ministries, diplomatic representatives, and international monitoring institutions.
Where can readers follow subsequent communiqués?
Direct official transcripts and bulletins are distributed via CNBC International Markets at https://www.cnbc.com/2026/10/30/novartis-remibrutinib-multiple-sclerosis.html.
Official Government & Primary Citations
- CNBC International Markets — https://www.cnbc.com/2026/10/30/novartis-remibrutinib-multiple-sclerosis.html
Get America’s Most Critical Breaking Alerts Instantly
Subscribe to receive automated, verified bulletins on severe weather, major recalls, national airspace travel, and emergency declarations directly in your inbox.
Most Popular Across America
Top trending dispatches and verified public interest records right now
Magnitude 5.0 Earthquake Strikes Near Volcano Islands, Japan region
Verified reporting recorded across Pagan region, Northern Mariana Islands indicates that a magnitude 5.0 earthquake was registered by USGS seismographs near Pagan region, Northern Mariana Islands at a depth of 129.4 kilometers.
Gale Warning issued September 22 at 3:00AM EDT until September 25 at 12:00AM EDT by NWS Newport/Morehead City NC in North Carolina
TORDDC The National Weather Service in Dodge City has issued a * Tornado Warning for... Central Pawnee County in south central Kansas... * Until 345 PM CDT. * At 320 PM CDT, a severe thunderstorm capable of producing a tornado was located.
Trump to headline "Golden Age" event with top officials, tech executives
President Trump is slated to speak on Tuesday in Washington at an event that features Elon Musk, Jensen Huang and others, according to invitation materials reviewed by CBS News.
This week on "Sunday Morning" (Sept. 27)
A look at the features for this week's broadcast of the Emmy-winning program, hosted by Jane Pauley.
More than 100 arrested as New Yorkers protest Netanyahu’s UN visit
Demonstrators blocked streets and marched towards UN headquarters as the Israeli PM addressed world leaders at UNGA.
Contrasting treatment of Israel and Palestine on display at the UN
Israel’s Prime Minister addressed the UN General Assembly in person, despite having an ICC arrest warrant.
Related US News & Bulletins
Binance hacker dumps a little-known 2017 token and it crashes 90%
According to reporting by CoinDesk FinTech & Crypto, The hacker dumped FUN and other smaller tokens into markets too small to absorb large selling, leading to price crashes.
worldAI’s real bottleneck is electricity. Who will pay for it?
According to reporting by Al Jazeera International, Big Tech’s nuclear power deals raise urgent questions about who will bear the cost of AI’s growing energy demands.
worldBP posts $8.5 billion third-quarter profit as oil prices soar
According to reporting by CNBC International Markets, BP posts $8.5 billion third-quarter profit as oil prices soar
worldBritain must sanction Israel, not just its settlers
According to reporting by Al Jazeera International, Israeli forces detained our parliamentary delegation and barred us from the West Bank. The violence is state policy.